All publications - Philippe Remy

G Meissner, W., Remy, P., Giordana, C., Maltête, D., Derkinderen, P., Houeto, J., Anheim, M., Benatru, I., Boraud, T., Brefel-Courbon, C., Carrière, N., Catala, H., Colin, O., Corvol, J., Damier, P., Dellapina, E., Devos, D., Drapier, S., Fabbri, M., Ferrier, V., Foubert-Samier, A., Frismand-Kryloff, S., Georget, A., Germain, C., Grimaldi, S., Hardy, C. , Hopes, L., Krystkowiak, P., Laurens, B., Lefaucheur, R., Mariani, L., Marques, A., Marse, C., Ory-Magne, F., Rigalleau, V., Salhi, H., Saubion, A., R W Stott, S., Thalamas, C., Thiriez, C., Tir, M., K Wyse, R., Benard, A., Rascol, O. & Study Group, L. (2024). Trial of Lixisenatide in Early Parkinson's Disease. The New England journal of medicine, 390(13), 1176-1185. doi:10.1056/NEJMoa2312323

Gendre, T. , Ovaska, H. , NGuyen, R. , Bachoud-Levi, A., Khellaf, M. & Remy, P. (2023). Acute ataxia induced by nitrous oxide abuse in young adults during the COVID-19 pandemic. Emergencias, 35(3), 225-227. doi:10.55633/s3me/E067.2023

Lunven, M., Hernandez Dominguez, K., Youssov, K., Hamet Bagnou, J., Fliss, R. , Vandendriessche, H., Bapst, B. , Morgado, G., Remy, P., Schubert, R. , Reilmann, R., Busse, M., Craufurd, D., Massart, R., Rosser, A. & Bachoud-Levi, A. (2023). A new approach to digitized cognitive monitoring: validity of the SelfCog in Huntington's disease. Brain communications, 5(2), fcad043. doi:10.1093/braincomms/fcad043

Cleret de Langavant, L., Roze, E., Petit, A. , Tressières, B., Gharbi-Meliani, A., Chaumont, H., Pierre Michel, P., Bachoud-Levi, A., Remy, P., Edragas, R. & Lannuzel, A. (2022). Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Movement disorders : official journal of the Movement Disorder Society, 37(12), 2355-2366. doi:10.1002/mds.29222

Mangin, J., Rivière, D., Duchesnay, E., Cointepas, Y., Gaura, V., Verny, C., Damier, P., Krystkowiak, P., Bachoud-Levi, A., Hantraye, P., Remy, P. & Douaud, G. (2020). Neocortical morphometry in Huntington's disease: Indication of the coexistence of abnormal neurodevelopmental and neurodegenerative processes. Neuroimage-Clinical, 26, 102211. doi:10.1016/j.nicl.2020.102211

García-Lorenzo, D., Lavisse, S., Leroy, C., Wimberley, C., Bodini, B., Remy, P., Veronese, M., Stankoff, B. & Bottaender , M. (2018). Validation of an automatic reference region extraction for the quantification of [18F]DPA-714 in dynamic brain PET studies. J Cerebr Blood Flow Metab , 38(2), 333-346. doi:10.1177/0271678X17692599

Wimberley, C., Lavisse, S., Brulon, V., Peyronneau, M., Leroy, C., Bodini, B., Remy, P., Stankoff, B., Buvat, I. & Bottlaender, M. (2018). Impact of Endothelial 18-kDa Translocator Protein on the Quantification of 18F-DPA-714. J Nucl Med, 59(2), 307-314. doi:10.2967/jnumed.117.195396

Wimberley, C., Lavisse, S., Brulon, V., Peyronneau, M., Kuhnast, B., Leroy, C., Remy, P., Stankoff, B. & Bottlaender, M. (2018). Impact of endothelial TSPO on the quantification of 18F-DPA714 in the normal human brain. , 59(2), 307-314. doi:10.2967/jnumed.117.195396

García-Lorenzo, D., Lavisse, S., Leroy, C., Wimberley, C., Bodini, B., Remy, P., Veronese, M., Turkheimer, F., Stankoff, B. & Bottlaender, M. (2017). Validation of an automatic reference region extraction for the quantification of [18F]DPA-714 in dynamic brain PET studies. Journal of cerebral blood flow and metabolism. doi:10.1177/0271678X17692599

Gaura, V., Lavisse, S., Payoux, P., Goldman, S., Verny, C., Krystkowiak, P., Damier, P., Supiot, F., Bachoud-Levi, A. & Remy, P. (2017). Association Between Motor Symptoms and Brain Metabolism in Early Huntington Disease. JAMA neurology, 74(9), 1088-1096. doi:10.1001/jamaneurol.2017.1200

Gaura, V., Lavisse, S., Payoux, P., Goldman, S., Verny, C., Krystkowiak, P., Damier, P., Supiot, F., Bachoud-Levi, A. & Remy, P. (2017). Relationship between motor symptoms and brain metabolism in early Huntington’s disease. JAMA Neurol , 74, 1088-1096

Villafane, G., Thiriez, C., Audureau, E., Straczek , C., Kerschen, P., Cormier-Dequaire , F., Van Der Gucht, A., Gurruchaga, J., Evangelista, E., Defer, G., Damier, P., Remy, P., Itti, E., Fenelon, G. & Quéré-Carne M, M. (2017). High-dose transdermal nicotine in Parkinson's disease patients: a randomized, open-label, blinded-endpoint evaluation phase 2 study. Eur J Neurol , 25, 120-127. doi:10.1111/ene.13474

Wimberley, C., Lavisse, S., Brulon, V., Peyronneau, M., Leroy, C., Bodini, B., Remy, P., Stankoff, B., Buvat, I. & Bottlaender, M. (2017). Impact of endothelial TSPO on the quantification of 18F-DPA-714. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. doi:10.2967/jnumed.117.195396

Visser, E., Keuken, M., Douaud, G., Gaura, V., Bachoud-Levi, A., Remy, P., Forstmann, B. & Jenkinson, M. (2016). Automatic segmentation of the striatum and globus pallidus using MIST: Multimodal Image Segmentation Tool. NeuroImage, 125, 479-497. doi:10.1016/j.neuroimage.2015.10.013

Lavisse, S., García-Lorenzo, D., Peyronneau, M., Bodini, B., Thiriez, C., Kuhnast, B., Comtat, C., Remy, P., Stankoff, B. & Bottlaender, M. (2015). Optimized Quantification of Translocator Protein Radioligand ¹⁸F-DPA-714 Uptake in the Brain of Genotyped Healthy Volunteers. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(7), 1048-54. doi:10.2967/jnumed.115.156083

Thiriez, C., Itti, E., Fenelon, G., Evangelista, E., Meignan, M., Cesaro, P. & Remy, P. (2015). Clinical routine use of dopamine transporter imaging in 516 consecutive patients. Journal of neurology, 262(4), 909-15. doi:10.1007/s00415-014-7634-y

Palfi, S., Gurruchaga, J., Ralph, G., Lepetit, H., Lavisse, S., Buttery, P., Watts, C., Miskin, J., Kelleher, M., Deeley, S., Iwamuro, H., Lefaucheur, J., Thiriez, C., Fenelon, G., Lucas, C., Brugières, P., Gabriel, I., Abhay, K., Drouot, X., Tani, N., Kas, A., Ghaleh, B., Le Corvoisier, P., Dolphin, P., Breen, D., Mason, S., Guzman, N., Mazarakis, N., Radcliffe, P., Harrop, R., Kingsman, S., Rascol, O., Naylor, S., Barker, R., Hantraye, P., Remy, P., Cesaro, P. & Mitrophanous, K. (2014). Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial. Lancet (London, England), 383(9923), 1138-46. doi:10.1016/S0140-6736(13)61939-X

Chaumeil, M., Valette, J., Baligand, C., Brouillet, E., Hantraye, P., Bloch, G., Gaura, V., Rialland, A., Krystkowiak, P., Verny, C., Damier, P., Remy, P., Bachoud-Levi, A., Carlier, P. & Lebon, V. (2012). pH as a biomarker of neurodegeneration in Huntington's disease: a translational rodent-human MRS study. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 32(5), 771-9. doi:10.1038/jcbfm.2012.15

Lavisse, S., Guillermier, M., Hérard, A., Petit, F., Delahaye, M., Van Camp, N., Ben Haim, L., Lebon, V., Remy, P., Dollé, F., Delzescaux, T., Bonvento, G., Hantraye, P. & Escartin, C. (2012). Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(32), 10809-18. doi:10.1523/JNEUROSCI.1487-12.2012

Allain, P., Gaura, V., Fasotti, L., Chauviré, V., Prundean, A., Sherer-Gagou, C., Bonneau, D., Bachoud-Levi, A., Dubas, F., Remy, P., Le Gall, D. & Verny, C. (2011). The neural substrates of script knowledge deficits as revealed by a PET study in Huntington's disease. Neuropsychologia, 49(9), 2673-84. doi:10.1016/j.neuropsychologia.2011.05.015

Shin, M., Jan, C., Jacquard, C., Jarraya, B., Callebert, J., Launay, J., Hantraye, P., Remy, P., Palfi, S. & Brouillet, E. (2011). Chronic systemic treatment with a high-dose proteasome inhibitor in mice produces akinesia unrelated to nigrostriatal degeneration. Neurobiology of aging, 32(11), 2100-2. doi:10.1016/j.neurobiolaging.2009.11.015

Thiriez, C., Villafane, G., Grapin, F., Fenelon, G., Remy, P. & Cesaro, P. (2011). Can nicotine be used medicinally in Parkinson's disease? Expert review of clinical pharmacology, 4(4), 429-36. doi:10.1586/ecp.11.27

Douaud, G., Behrens, T., Poupon, C., Cointepas, Y., Jbabdi, S., Gaura, V., Golestani, N., Krystkowiak, P., Verny, C., Damier, P., Bachoud-Levi, A., Hantraye, P. & Remy, P. (2009). In vivo evidence for the selective subcortical degeneration in Huntington's disease. NeuroImage, 46(4), 958-66. doi:10.1016/j.neuroimage.2009.03.044

Kas, A., Bottlaender, M., Gallezot, J., Vidailhet, M., Villafane, G., Grégoire, M., Coulon, C., Valette, H., Dollé, F., Ribeiro, M., Hantraye, P. & Remy, P. (2009). Decrease of nicotinic receptors in the nigrostriatal system in Parkinson's disease. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 29(9), 1601-8. doi:10.1038/jcbfm.2009.74

Payoux, P., Remy, P., Miloudi, M., Houeto, J., Stadler, C., Bejjani, B., Yelnik, J., Samson, Y., Rascol, O., Agid, Y. & Damier, P. (2009). Contrasting changes in cortical activation induced by acute high-frequency stimulation within the globus pallidus in Parkinson's disease. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 29(2), 235-43. doi:10.1038/jcbfm.2008.107

Ribeiro, M., Thobois, S., Lohmann, E., Du Montcel, S., Lesage, S., Pelissolo, A., Dubois, B., Mallet, L., Pollak, P., Agid, Y., Broussolle, E., Brice, A., Remy, P. & French Parkinson'S Disease Genetics Study, G. (2009). A multitracer dopaminergic PET study of young-onset parkinsonian patients with and without parkin gene mutations. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 50(8), 1244-50. doi:10.2967/jnumed.109.063529

Lefaucheur, J., Gurruchaga, J., Pollin, B., Von Raison, F., Mohsen, N., Shin, M., Ménard-Lefaucheur, I., Oshino, S., Kishima, H., Fenelon, G., Remy, P., Cesaro, P., Gabriel, I., Brugières, P., Keravel, Y. & Nguyen, J. (2008). Outcome of bilateral subthalamic nucleus stimulation in the treatment of Parkinson's disease: correlation with intra-operative multi-unit recordings but not with the type of anaesthesia. European neurology, 60(4), 186-99. doi:10.1159/000148246

Ribeiro, M., Idbaih, A., Thomas, C., Remy, P., Martin-Duverneuil, N., Samson, Y., Donadieu, J. & Hoang-Xuan, K. (2008). 18F-FDG PET in neurodegenerative Langerhans cell histiocytosis : results and potential interest for an early diagnosis of the disease. Journal of neurology, 255(4), 575-80. doi:10.1007/s00415-008-0751-8

Teichmann, M., Gaura, V., Démonet, J., Supiot, F., Delliaux, M., Verny, C., Renou, P., Remy, P. & Bachoud-Levi, A. (2008). Language processing within the striatum: evidence from a PET correlation study in Huntington's disease. Brain : a journal of neurology, 131(Pt 4), 1046-56. doi:10.1093/brain/awn036

Kas, A., Payoux, P., Habert, M., Malek, Z., Cointepas, Y., El Fakhri, G., Chaumet-Riffaud, P., Itti, E. & Remy, P. (2007). Validation of a standardized normalization template for statistical parametric mapping analysis of 123I-FP-CIT images. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 48(9), 1459-67. doi:10.2967/jnumed.106.038646

Krystkowiak, P., Gaura, V., Labalette, M., Rialland, A., Remy, P., Peschanski, M. & Bachoud-Levi, A. (2007). Alloimmunisation to donor antigens and immune rejection following foetal neural grafts to the brain in patients with Huntington's disease. PloS one, 2(1), e166. doi:10.1371/journal.pone.0000166

Mallet, L., Schüpbach, M., N'Diaye, K., Remy, P., Bardinet, E., Czernecki, V., Welter, M., Pelissolo, A., Ruberg, M., Agid, Y. & Yelnik, J. (2007). Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behavior. Proceedings of the National Academy of Sciences of the United States of America, 104(25), 10661-6. doi:10.1073/pnas.0610849104

Traykov, L., Raoux, N., Latour, F., Gallo, L., Hanon, O., Baudic, S., Bayle, C., Wenisch, E., Remy, P. & Rigaud, A. (2007). Executive functions deficit in mild cognitive impairment. Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology, 20(4), 219-24. doi:10.1097/WNN.0b013e31815e6254

Bachoud-Levi, A., Gaura, V., Brugières, P., Lefaucheur, J., Boissé, M., Maison, P., Baudic, S., Ribeiro, M., Bourdet, C., Remy, P., Cesaro, P., Hantraye, P. & Peschanski, M. (2006). Persistent benefit of foetal neural transplants in patients with Huntington's disease six years after surgery. Lancet Neurol(5 ), 303-309

Bachoud-Levi, A., Gaura, V., Brugières, P., Lefaucheur, J., Boissé, M., Maison, P., Baudic, S., Ribeiro, M., Bourdet, C., Remy, P., Cesaro, P., Hantraye, P. & Peschanski, M. (2006). Effect of fetal neural transplants in patients with Huntington's disease 6 years after surgery: a long-term follow-up study. The Lancet. Neurology, 5(4), 303-9. doi:10.1016/S1474-4422(06)70381-7

Baudic, S., Barba, G., Thibaudet, M., Smagghe, A., Remy, P. & Traykov, L. (2006). Executive function deficits in early Alzheimer's disease and their relations with episodic memory. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 21(1), 15-21. doi:10.1016/j.acn.2005.07.002

Benaderette, S., Zanotti Fregonara, P., Apartis, E., Nguyen, C., Trocello, J., Remy, P., Devaux, J., Askienazy, S. & Vidailhet, M. (2006). Psychogenic parkinsonism: a combination of clinical, electrophysiological, and [(123)I]-FP-CIT SPECT scan explorations improves diagnostic accuracy. Movement disorders : official journal of the Movement Disorder Society, 21(3), 310-7. doi:10.1002/mds.20720

Douaud, G., Gaura, V., Ribeiro, M., Lethimonnier, F., Maroy , R., Verny, C., Krystkowiak, P., Damier, P., Bachoud-Levi, A., Hantraye, P. & Remy, P. (2006). Distribution of grey matter atrophy in Huntington's disease patients: A combined ROI-based and voxel-based morphometric study. NeuroImage, 32(4), 1562-1575. doi:10.1016/j.neuroimage.2006.05.057

Douaud, G., Gaura, V., Ribeiro, M., Lethimonnier, F., Maroy , R., Verny, C., Krystkowiak, P., Damier, P., Bachoud-Levi, A., Hantraye, P. & Remy, P. (2006). Grey matter atrophy in Huntington disease: a combined ROI-based and voxel-based morphometric study. NeuroImage(104), 10661-10666

Remy, P., Doder, M., Lees, A., Turjanski, N. & Brooks, D. (2005). Decrease of dopamine and noradrenaline innervation in the limbic system of depressed Parkinson’s disease patients. Brain(128 ), 1314-1322

Bloch, J., Bachoud-Levi, A., Déglon, N., Lefaucheur, J., Winkel, L., Palfi, S., Nguyen, J., Bourdet, C., Gaura, V., Remy, P., Brugières, P., Boissé, M., Baudic, S., Cesaro, P., Hantraye, P., Aebischer, P. & Peschanski, M. (2004). Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: Results of a phase I study. Human Gene Therapy, 15(10), 968-975. doi:10.1089/hum.2004.15.968

Drouot, X., Oshino, S., Jarraya, B., Besret, L., Kishima, H., Remy, P., Dauguet, J., Lefaucheur, J., Dollé, F., Condé, F., Bottlaender, M., Peschanski, M., Keravel, Y., Hantraye, P. & Palfi, S. (2004). Functional recovery in a primate model of Parkinson's disease following motor cortex stimulation. Neuron, 44(5), 769-78. doi:10.1016/j.neuron.2004.11.023

Gaura, V., Bachoud-Levi, A., Ribeiro, M., Nguyen, J., Frouin, V., Baudic, S., Brugières, P., Mangin, J., Boissé, M., Palfi, S., Cesaro, P., Samson, Y., Hantraye, P., Peschanski, M. & Remy, P. (2004). Striatal neural grafting improves cortical metabolism in Huntington's disease patients. Brain : a journal of neurology, 127(Pt 1), 65-72. doi:10.1093/brain/awh003

Payoux, P., Remy, P., Damier, P., Miloudi, M., Loubinoux, I., Pidoux, B., Gaura, V., Rascol, O., Samson, Y. & Agid, Y. (2004). Subthalamic nucleus stimulation reduces abnormal motor cortical overactivity in Parkinson disease. Archives of neurology, 61(8), 1307-13. doi:10.1001/archneur.61.8.1307

Whone, A., Bailey, D., Remy, P., Pavese, N. & Brooks, D. (2004). A technique for standardized central analysis of 6-(18)F-fluoro-L-DOPA PET data from a multicenter study. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 45(7), 1135-45.

Cochen, V., Ribeiro, M., Nguyen, J., Gurruchaga, J., Villafane, G., Loc'H, C., Defer, G., Samson, Y., Peschanski, M., Hantraye, P., Cesaro, P. & Remy, P. (2003). Transplantation in Parkinson's disease: PET changes correlate with the amount of grafted tissue. Movement disorders : official journal of the Movement Disorder Society, 18(8), 928-32. doi:10.1002/mds.10463

Remy, P. & Samson, Y. (2003). The role of dopamine in cognition: evidence from functional imaging studies. Current opinion in neurology, 16 Suppl 2, S37-41.

Thobois, S., Ribeiro, M., Lohmann, E., Durr, A., Pollak, P., Rascol, O., Guillouet, S., Chapoy, E., Costes, N., Agid, Y., Remy, P., Brice, A., Broussolle, E. & French Parkinson'S Disease Genetics Study, G. (2003). Young-onset Parkinson disease with and without parkin gene mutations: a fluorodopa F 18 positron emission tomography study. Archives of neurology, 60(5), 713-8. doi:10.1001/archneur.60.5.713

Whone, A., Watts, R., Stoessl, A., Davis, M., Reske, S., Nahmias, C., Lang, A., Rascol, O., Ribeiro, M., Remy, P., Poewe, W., Hauser, R., Brooks, D. & Real-Pet Study, G. (2003). Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study. Annals of neurology, 54(1), 93-101. doi:10.1002/ana.10609

Bachoud-Levi, A., Remy, P., Brugières, P., Lefaucheur, J., Bourdet, C., Baudic, S., Gaura, V., Maison, P., Haddad , B., Boissé, M., Grandmougin , T., Jény , R., Bartolomeo, P., Dalla Barba , G., Degos, J., Lisovoski , F., Pailhous , E., Cesaro, P., Hantraye, P. & Peschanski, M. (2000). Motor and cognitive improvements in patients with Huntington’s disease after neural transplantation. Lancet(356), 1975-1979

Bachoud-Levi, A., Déglon, N., Nguyen, J., Bloch, J., Bourdet, C., Winkel, L., Remy, P., Goddard, M., Lefaucheur, J., Brugières, P., Baudic, S., Cesaro, P., Peschanski, M. & Aebischer, P. (2000). Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF. Human Gene Therapy, 11(12), 1723-1729. doi:10.1089/10430340050111377

Bachoud-Levi, A., Bourdet, C., Brugières, P., Nguyen, J., Grandmougin , T., Haddad , B., Jény , R., Bartolomeo, P., Boissé, M., Barba, G., Degos, J., Ergis, A., Lefaucheur, J., Lisovoski , F., Pailhous , E., Remy, P., Palfi, S., Defer, G., Cesaro, P., Hantraye, P. & Peschanski, M. (2000). Safety and tolerability assessment of intrastriatal neural allografts in five patients with Huntington's disease. Experimental Neurology, 161(1), 194-202. doi:10.1006/exnr.1999.7239

Bachoud-Levi, A., Remy, P., Nguyen, J., Brugières, P., Lefaucheur, J., Bourdet, C., Baudic, S., Gaura, V., Maison, P., Haddad , B., Boissé, M., Grandmougin , T., Jény , R., Bartolomeo, P., Barba, G., Degos, J., Lisovoski , F., Ergis, A., Pailhous , E., Cesaro, P., Hantraye, P. & Peschanski, M. (2000). Motor and cognitive improvements in patients with Huntington's disease after neural transplantation. Lancet, 356(9246), 1975-1979. doi:10.1016/S0140-6736(00)03310-9

Remy, P., Zilbovicius, M., Degos, J., Bachoud-Levi, A., Rancurel, G., Cesaro, P. & Samson, Y. (1999). Somatosensory cortical activations are suppressed in patients with tactile extinction: a PET study. Neurology. doi:10.1212/wnl.52.3.571